サメ抽出脂質による悪性疾患治療およびがん増殖や転移の抑制報告

Lipid-rich extracts from several shark organs have strong anti-angiogenic activity. Experiments using both culture and animal models established that dilution of this extract with olive enhanced the activity synergistically.

This combination has also been found to be very effective at inhibiting the growth of melanomas in mice. However, it was found to have relatively minimal effect at inhibiting the growth of cultured melanoma cells and of a number of other types of tumour cells in culture. This suggested that the shark oil olive oil mix (known as Super Maco) had little effect on the cancer cells themselves. Thus the in vivo inhibitory effect must be predominantly on the angiogenesis and other activities that are associated with cancer growth and spread. It has also been established that the Super Maco was non-toxic in animals.

An investigation of the mechanism of action of Super Maco has shown that it can inhibit the activity of several growth factors that are known to promote angiogenesis. For one of these, VEGGF, the Super Maco binds to its receptors and as a result inhibits the activation of angiogenesis.

A second generation preparation based on Super Maco is being researched. A unique extract has been prepared from Phellinus linteus mushroom and combined with Super Maco. This mushroom extract is β-glucan free and is also lipid-rich. Several combinations of these have been shown to have increased anti-angiogenesis activity. When tested on melanoma in mice these mixtures were even more potent than the Super Maco or mushroom extract alone. There is also evidence that this mix may be active when used for treating lung cancer. Safely and non-toxicity has also been confirmed for this product.

Research is currently in progress to evaluate the effectiveness of lipid-rich extracts from other species of mushroom when combined with Super Maco.

Integrated medication should be considered more seriously for treatment of malignant diseases such as cancer. The Second Complimentary and Alternative/Integrated Medicine Forum had been held at Akihabara Convention Center in Tokyo in November 12 2005, sponsored by a newly established NPO “Association for Life Style Related Diseases and Integrated Medicine”.

Lipid fraction extracted from shark muscle came under the spotlight because of its unique biological functions. Dr. P. Davis, the University of Otago in New Zealand, and Prof. K-Y. Park, Pusan National University, presented the research history and mechanism of anti-angiogenic activities of shark lipids extract.

Prof. W. Koestler, president of the Austrian Society of Oncology, presented clinical data of significant effects of shark lipids in combination with other health food supplement on QOL of very advanced cancer patients. Dr. O. Mizukami at Tokyo Adventist Hospital, who has been using shark lipids product for his cancer patients, explained importance of integrative medicine. Dr. S. Grekin, Michigan State University, presented clinical benefits of shark lipids for psoriasis patients.

Potential application of shark lipids extract for malignant disease will be presented using clinical case reports in EU, US and Japan.