第５回国際研究皮膚科学学会

2008年05月14日

2008年5月14日(水)～17日(土)に京都国際会館で開催された第５回国際研究皮膚科学学会で、マイタケ抽出物に関する2つの報告がありました。

マイタケエタノール抽出物含有クリームによって改善された健常者および乾皮症患者の皮膚バリアー機能
マイタケエタノール抽出物によって増強されたノビレチン(ポリメトキシフラボノイド)の血管新生抑制作用および腫瘍形成抑制作用(in vitro)

マイタケエタノール抽出物含有クリームによって改善された健常者および乾皮症患者の皮膚バリアー機能

Improvement of skin barrier by a cream containing an ethanol extract of Maitake mushroom on normal and xerosis skin

Mie Nagao¹, Takashi Sato², Akira Ito², Shigeru Matsuzaki³ and Masao Takahashi^1,4

Heimat Co., Ltd (Japan)
Department of Biochemistry and Molecular Biology, Tokyo University of Pharmacy and Life Sciences
Yoshii Central Clinic (Japan)
Immuno Research Ltd (New Zealand)

Introduction

Xerosis (dry skin) is defined as dehydration of stratum corneum and characterized by scales, fissures, erosion, and calluses on the skin, which thereby impairs the skin barrier function. In addition, most xerosis patients exhibit uncomfortable itching feelings or pain. Thus, structural and functional improvement of the impaired skin barrier may facilitate a treatment for xerosis and improve the quality of life of patients. On the other hand, sebum secreted from sebaceous glands plays an important role for maintaining physiological functions by forming a biological barrier on the skin. Since we found novel evidence that an ethanol extract of Grifola frondosa (Maitake mushroom) fruiting body, which is termed Gripin^®, augments the sebum production in hamster sebocytes in vivo and in vitro, the Maitake extract might be an effective means of treating xerosis. In the present study, we performed a clinical trial investigation using a cream containing 0.2% Maitake ethanol extract (Maitake cream) (舞潤^®, MaiJun) on the posterior antebrachial and crural skin of 60 patients with moderate to severe xerosis, and on the posterior antebrachial skin of healthy volunteers.

Conclusion

These results suggest that the Maitake cream is useful for not only remission and/or cure of xerosis but also enhancement of moisturization in healthy skin by the mechanism whereby the Maitake extract augments sebum production to restore the cutaneous barrier function.

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マイタケエタノール抽出物によって増強されたノビレチン(ポリメトキシフラボノイド)の血管新生抑制作用および腫瘍形成抑制作用(in vitro)

An ethanol extract of Grifola frondosa (Maitake mushroom) enhances the anti-angiogenic and anti-tumorigenic actions of polymethoxyflavonoid, nobiletin, in vitro

Takashi Sato¹, Mie Nagao², Masao Takahashi^2,3 and Akira Ito¹

Department of Biochemistry and Molecular Biology, Tokyo University of Pharmacy and Life Sciences
Heimat Co., Ltd (Japan)
Immuno Research Ltd (New Zealand)

Introduction

Flavonoids from medicinal plants possess pharmacological effects for preventing tumor progression by inhibiting tumor-cell proliferation, neoplastic angiogenesis, and tumor invasion. We reported that a citrus polymethoxyflavonoid, nobiletin (5,6,7,8,3′,4′-hexamethoxy flavone), exhibits antitumor-invasive and antitumorigenic actions in vivo and in vitro. In addition, water extract of Grifola frondosa (Maitake mushroom) has been reported to possess antitumor effects by enhancing the immune system. However, the anti-angiogenic actions of nobiletin and Maitake mushroom extract remain unclear. In the present study, we examined whether nobiletin and an ethanol extract of the Maitake mushroom (Maitake extract), which is termed Gripin^®, influenced the proliferation of human melanoma Mewo cells and the tube formation of human microvascular endothelial cells (HMVEC).

Conclusion

These results suggest that nobiletin exhibits an anti-angiogenic effect by inhibiting the tube formation of vascular endothelial cells. Moreover, the combination of Maitake extract and nobiletin is likely to be a novel clinical strategy for cancer therapy against melanoma to prevent both angiogenesis and tumorigenesis.

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