Angiogenesis in Rheumatoid Arthritis

Rheumatoid Arthritis is an inflammatory autoimmune disease that attacks the joints of hands and feet, causing pain and deformation of the joint.

Rheumatoid arthritis mainly causes inflammatory symptoms. Inflammation inside of the joint cavity is caused by the extravascular migration of inflammatory cells, such as macrophages and T-lymphocytes that come from the small blood vessels in the joint fluid cavity itself. By penetration of inflammatory cells into the joint cavity, inflammatory and angiogenic factors are produced and also promote angiogenesis that fail to retain control of the inflammatory response.