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Sebum secreted by the sebaceous glands plays a role in the biological defense mechanism. Therefore, it is suggested that a decrease in sebum secretion causes a decrease in biological barrier function. In fact, a decrease in sebum secretion with aging causes dry skin, accompanying pruritus is also a factor that causes mental stress. That is to say, substances that promote sebum production are expected to be effective in preventing and improving dry skin. At last year’s meeting, we reported that Grifola frondosa extract (Gripin®) promotes sebum production in hamster sebaceous gland cells in vivo and in vitro. In this study, we investigated the effect of Gripin on improving dry skin in elderly people with mild to severe dry skin based on skin desquamation. Furthermore, we examined the dynamics of sebum and surface water content in the skin of healthy people who applied Gripin®.
60 men and women with dry skin aged 70 years or older were given 0.2% Gripin® cream to apply on the lower arms and legs once a day for 5weeks. The efficacy of Gripin® was evaluated based on skin desquamation. In addition, 15 healthy men and women aged 20 to 60 years were given 0.2% Gripin® cream or cream substrate on the left forearm 3 times a day for 4 weeks. Epidermal sebum and water content were measured with the Corneometer CM825PC 2 hours after washing the application area.
One week of Gripin® cream applied to elderly people with dry skin improved scales and cracks on the lower leg and dorsal of the feet in most subjects. The effect of 5 weeks of Gripin® cream application was observed to improve symptoms from severe to moderate or moderate to low. In addition, Gripin® cream increased epidermal sebum and water content in healthy subjects. This facilitating effect was observed from the next day of application, and it was found to be persistent.
