{"id":586,"date":"2020-12-28T15:27:28","date_gmt":"2020-12-28T06:27:28","guid":{"rendered":"https:\/\/heimat-ltd.com\/vn\/?p=586"},"modified":"2020-12-28T15:27:28","modified_gmt":"2020-12-28T06:27:28","slug":"macolipin","status":"publish","type":"post","link":"https:\/\/heimat-ltd.com\/vn\/resources\/macolipin.html","title":{"rendered":"Macolipin (Lipid chi\u1ebft xu\u1ea5t t\u1eeb c\u00e1 m\u1eadp)"},"content":{"rendered":"
Macolipin l\u00e0 m\u1ed9t ch\u1ea5t b\u00e9o \u0111\u1ed9c nh\u1ea5t \u0111\u01b0\u1ee3c chi\u1ebft xu\u1ea5t t\u1eeb \u200b\u200bc\u00e1 m\u1eadp. N\u00f3 c\u00f3 \u0111\u1eb7c t\u00ednh \u1ee9c ch\u1ebf h\u00ecnh th\u00e0nh m\u1ea1ch m\u1ea1nh, c\u00f3 gi\u00e1 tr\u1ecb \u0111\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a kh\u1ed1i u v\u00e0 di c\u0103n trong b\u1ec7nh ung th\u01b0. N\u00f3 c\u0169ng l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 trong c\u01a1 ch\u1ebf b\u1ec7nh sinh v\u00e0 s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a t\u1ea5t c\u1ea3 c\u00e1c r\u1ed1i lo\u1ea1n li\u00ean quan \u0111\u1ebfn h\u00ecnh th\u00e0nh m\u1ea1ch bao g\u1ed3m h\u1ed9i ch\u1ee9ng chuy\u1ec3n h\u00f3a, b\u1ec7nh v\u1ea9y n\u1ebfn, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, tho\u00e1i h\u00f3a \u0111i\u1ec3m v\u00e0ng, b\u1ec7nh v\u00f5ng m\u1ea1c ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 c\u00e1c r\u1ed1i lo\u1ea1n da li\u00ean quan \u0111\u1ebfn tu\u1ed5i t\u00e1c. H\u00ecnh th\u00e0nh m\u1ea1ch c\u00f3 ngh\u0129a l\u00e0 s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c m\u1ea1ch m\u00e1u m\u1edbi, m\u1eb7c d\u00f9 l\u00e0 m\u1ed9t ch\u1ee9c n\u0103ng thi\u1ebft y\u1ebfu trong s\u1ef1 ph\u00e1t tri\u1ec3n b\u00ecnh th\u01b0\u1eddng v\u00e0 sinh l\u00fd c\u1ee7a c\u01a1 th\u1ec3, nh\u01b0ng khi li\u00ean quan \u0111\u1ebfn ung th\u01b0 v\u00e0 c\u00e1c tr\u1ea1ng th\u00e1i b\u1ec7nh kh\u00e1c, n\u00f3 c\u1ea7n \u0111\u01b0\u1ee3c \u1ee9c ch\u1ebf. \u0110o\u1ea1n tr\u00edch sau \u0111\u00e2y t\u1eeb m\u1ed9t b\u1ea3n t\u00f3m t\u1eaft, v\u1edbi c\u00e1c ghi ch\u00fa gi\u1ea3i th\u00edch b\u1ed5 sung, m\u00f4 t\u1ea3 b\u1eb1ng ch\u1ee9ng th\u1ef1c nghi\u1ec7m v\u1ec1 hi\u1ec7u qu\u1ea3 c\u1ee7a Macolipin trong vi\u1ec7c \u1ee9c ch\u1ebf s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea1ch.<\/br>\r\n\r\n
Ch\u1ea5t lipid chi\u1ebft xu\u1ea5t t\u1eeb \u200b\u200bc\u00e1 m\u1eadp n\u00e0y \u0111\u1eb7c bi\u1ec7t m\u1ea1nh trong ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng h\u00ecnh th\u00e0nh m\u1ea1ch. Trong c\u00e1c th\u00ed nghi\u1ec7m trong ph\u00f2ng th\u00ed nghi\u1ec7m, vi\u1ec7c \u0111i\u1ec1u ch\u1ebf lipid chi\u1ebft xu\u1ea5t t\u1eeb \u200b\u200bc\u00e1 m\u1eadp (Macolipin) r\u1ea5t gi\u00e0u axit b\u00e9o kh\u00f4ng b\u00e3o h\u00f2a (\u0111\u1eb7c bi\u1ec7t l\u00e0 axit docosahexaenoic), t\u1ea1o ra s\u1ef1 \u1ee9c ch\u1ebf 50% s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea1ch \u1edf ch\u1ec9 5\u00b5g \/ ml. Khi d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng In Vivo Macolipin l\u00e0m gi\u1ea3m 50% qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh m\u1ea1ch \u1edf 17mg \/ kg th\u1ec3 tr\u1ecdng. D\u1ea7u \u00f4 liu \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf trong v\u00f2ng \u0111\u1ed9ng m\u1ea1ch ch\u1ee7 ho\u1eb7c c\u00e1c m\u00f4 h\u00ecnh In Vivo. Tuy nhi\u00ean, Macolipin, khi k\u1ebft h\u1ee3p v\u1edbi d\u1ea7u \u00f4 liu (t\u1ef7 l\u1ec7 1: 9) c\u00f3 hi\u1ec7u l\u1ef1c g\u1ea5p \u0111\u00f4i trong h\u1ec7 th\u1ed1ng In Vitro.<\/br>\r\n\r\n
C\u00e1c th\u00ed nghi\u1ec7m ch\u1ec9 ra r\u1eb1ng s\u1ef1 k\u1ebft h\u1ee3p n\u00e0y c\u00f3 th\u1ec3 ph\u1ee7 nh\u1eadn t\u00e1c \u0111\u1ed9ng k\u00edch th\u00edch c\u1ee7a c\u00e1c y\u1ebfu t\u1ed1 nh\u01b0 VEGF, FGF-2 v\u00e0 TGF-\u03b2 (\u0110\u00e2y l\u00e0 nh\u1eefng y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng k\u00edch th\u00edch s\u1ef1 k\u1ebft n\u1ed1i c\u1ee7a kh\u1ed1i u v\u1edbi c\u00e1c m\u1ea1ch m\u00e1u ch\u00ednh, do \u0111\u00f3 cho ph\u00e9p kh\u1ed1i u ph\u00e1t tri\u1ec3n v\u00e0 di c\u0103n). C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u0169ng g\u1ee3i \u00fd r\u1eb1ng h\u1ed7n h\u1ee3p Macolipin\/d\u1ea7u \u00f4 liu (t\u1ef7 l\u1ec7 1:9) l\u00e0 m\u1ed9t s\u1ea3n ph\u1ea9m t\u1ef1 nhi\u00ean c\u00f3 ho\u1ea1t t\u00ednh m\u1ea1nh c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng t\u1ea1o m\u1ea1ch \u0111\u00e1ng k\u1ec3. Ch\u1ee9c n\u0103ng ch\u1ed1ng t\u1ea1o m\u1ea1ch c\u1ee7a Macolipin th\u00f4ng qua vi\u1ec7c \u1ee9c ch\u1ebf s\u1ef1 g\u1eafn k\u1ebft c\u1ee7a VEGF v\u00e0 c\u00e1c th\u1ee5 th\u1ec3 c\u1ee7a n\u00f3 (VEGFR-2 v\u00e0 VEGFR-1) v\u00e0 \u1ee9c ch\u1ebf s\u1ef1 phosphoryl h\u00f3a tyrosine c\u1ee7a th\u1ee5 th\u1ec3 VEGF trong con \u0111\u01b0\u1eddng d\u1eabn truy\u1ec1n t\u00edn hi\u1ec7u th\u1ee5 th\u1ec3 VEGF. (N\u00f3i m\u1ed9t c\u00e1ch kh\u00e1i qu\u00e1t, \u0111i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 \u1ee9c ch\u1ebf c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng b\u00e1m v\u00e0o c\u00e1c v\u1ecb tr\u00ed g\u1eafn c\u1ee7a ch\u00fang tr\u00ean m\u1ea1ch m\u00e1u, c\u00e1c qu\u00e1 tr\u00ecnh ti\u1ebfp theo c\u1ea7n thi\u1ebft \u0111\u1ec3 cho ph\u00e9p t\u00edn hi\u1ec7u b\u1eaft \u0111\u1ea7u h\u00ecnh th\u00e0nh m\u1ea1ch b\u1ecb ng\u0103n ch\u1eb7n).<\/br>\r\n\r\n
C\u00e1c nghi\u00ean c\u1ee9u th\u1ef1c nghi\u1ec7m v\u00e0 In Vivo \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean Macolipin, m\u1ed9t chi\u1ebft xu\u1ea5t lipid \u0111\u1ed9c \u0111\u00e1o c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb m\u1ed9t s\u1ed1 lo\u00e0i c\u00e1 m\u1eadp cho th\u1ea5y r\u1eb1ng s\u1ea3n ph\u1ea9m c\u00f3 gi\u00e1 tr\u1ecb nh\u01b0 m\u1ed9t th\u00e0nh ph\u1ea7n ch\u1ed1ng t\u1ea1o m\u1ea1ch t\u1ef1 nhi\u00ean. Macolipin \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u1ec1 \u0111\u1ed9 an to\u00e0n v\u00e0 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 kh\u00f4ng \u0111\u1ed9c h\u1ea1i v\u00e0 kh\u00f4ng g\u00e2y d\u1ecb t\u1eadt kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u1ed1i v\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a thai nhi trong thai k\u1ef3) t\u1ea1i Vi\u1ec7n Tama, Ph\u00f2ng th\u00ed nghi\u1ec7m Nghi\u00ean c\u1ee9u Th\u1ef1c ph\u1ea9m Nh\u1eadt B\u1ea3n.<\/br>\r\n\r\n\r\n
Ngu\u1ed3n tham kh\u1ea3o:<\/strong><\/br>\r\n\r\n
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Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983 Dec 16;65(1-2):55-63.<\/br>","protected":false},"excerpt":{"rendered":"Macolipin l\u00e0 m\u1ed9t ch\u1ea5t b\u00e9o \u0111\u1ed9c nh\u1ea5t \u0111\u01b0\u1ee3c chi\u1ebft xu\u1ea5t t\u1eeb \u200b\u200bc\u00e1 m\u1eadp. N\u00f3 c\u00f3 \u0111\u1eb7c t\u00ednh \u1ee9c ch\u1ebf h\u00ecnh th\u00e0nh m\u1ea1ch m\u1ea1nh, c\u00f3 gi\u00e1 tr\u1ecb \u0111\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a kh\u1ed1i u v\u00e0 di c\u0103n trong b\u1ec7nh ung th\u01b0. N\u00f3 c\u0169ng l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 trong c\u01a1 ch\u1ebf b\u1ec7nh sinh v\u00e0 s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a t\u1ea5t c\u1ea3 c\u00e1c r\u1ed1i lo\u1ea1n li\u00ean quan \u0111\u1ebfn h\u00ecnh th\u00e0nh m\u1ea1ch bao g\u1ed3m h\u1ed9i ch\u1ee9ng chuy\u1ec3n h\u00f3a, b\u1ec7nh v\u1ea9y n\u1ebfn, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, tho\u00e1i h\u00f3a \u0111i\u1ec3m v\u00e0ng, b\u1ec7nh v\u00f5ng m\u1ea1c ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 c\u00e1c r\u1ed1i lo\u1ea1n da li\u00ean quan \u0111\u1ebfn tu\u1ed5i t\u00e1c. H\u00ecnh th\u00e0nh m\u1ea1ch c\u00f3 ngh\u0129a l\u00e0 s\u1ef1 h\u00ecnh th\u00e0nh […]","protected":false},"author":1,"featured_media":558,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[9],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/heimat-ltd.com\/vn\/wp-json\/wp\/v2\/posts\/586"}],"collection":[{"href":"https:\/\/heimat-ltd.com\/vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/heimat-ltd.com\/vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/heimat-ltd.com\/vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/heimat-ltd.com\/vn\/wp-json\/wp\/v2\/comments?post=586"}],"version-history":[{"count":2,"href":"https:\/\/heimat-ltd.com\/vn\/wp-json\/wp\/v2\/posts\/586\/revisions"}],"predecessor-version":[{"id":588,"href":"https:\/\/heimat-ltd.com\/vn\/wp-json\/wp\/v2\/posts\/586\/revisions\/588"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/heimat-ltd.com\/vn\/wp-json\/wp\/v2\/media\/558"}],"wp:attachment":[{"href":"https:\/\/heimat-ltd.com\/vn\/wp-json\/wp\/v2\/media?parent=586"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/heimat-ltd.com\/vn\/wp-json\/wp\/v2\/categories?post=586"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/heimat-ltd.com\/vn\/wp-json\/wp\/v2\/tags?post=586"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}