Targeting females in their late 40’s to early 50’s, the results showed that the more wrinkles
they have, the lower is their bone density. The relationship between wrinkles and bone density is not only recognized in the bones of the face, but also in the hip bones, lumbar vertebra, heels and other parts of the body. Wrinkles and elasticity of the skin and the bone density are relate to collagen, therefore disorders of collagen metabolism caused by aging together with decreased levels of hormones invokes osteoporosis in the bones and wrinkles in the skin.
For the changes of the skull condition with aging among 120 men and women between the age of 20 to the age of 65, it was revealed that the osteoporosis of skull significantly related to wrinkles, sagging and the shape of the face. Facial lines around the eyes gradually spread widely with aging and this causes the wrinkles around the eyes, puffy eyes and slackness of the eyelids which tends to make the person look older.